How to block pain?

Posted by Fatimah Imah Kamis, 19 Mei 2011 0 comments
How to block pain? Intended to block pain and reduce or eliminate pain. Many ways can be done to block pain, based on understanding the mechanisms of pain:

1. Blocking the formation of pain mediators, particularly PG, namely by providing analgesic steroids (prednisone, dexamethasone), or nonsteroidal (aspirin, paracetamol, ibuprofen, etc.). Steroidal analgesic (NSAID) is the more prominent is the nature antiinflamasinya (inflammatory), while most other nonsteroidal antipyretic analgesics are also some anti-inflammatory properties. (NSAID = Non Steroid Anti Inflammatory Drugs.)

2. Block the delivery of pain by the nerve fibers can be made through anesthesia (drug), both locally (in place of pain stimuli occurred only) or systemic (whole body's nervous.) Lidocaine spray / injection (in a tooth extraction, circumcision) is an example of local anesthesia. There are also a variety of anesthesia given via intravenous injection (into veins), and even now many are given through the spinal cord, especially if the desired effects of the drug very quickly as in the operation Cesaria section (cesarean delivery).
3. Central block pain / pain receptors in the brain, ie, with narcotic analgesics (morphine, pethidin). Only the form of a narcotic analgesic that is able to penetrate the barrier between blood and brain (blood brain barrier) that can block pain very much. Steroidal analgesics, anesthetics, and narcotic analgesics may only be given by a physician (on prescription), while non-steroidal analgesics can be bought freely by consumers.
Jakarta-Scientists discover enzyme in the brain that affect the meaning of pain. This could be a new target in the fight against chronic pain in humans with cancer.

In a study published in Science magazine, scientists from Canada and South Korea say they managed to set the level of pain by blocking certain enzymes in the brain.

It gives a basic understanding of brain mechanisms related to chronic pain involves, write the study's lead author Min Zhuo, professor of physiology at the University of Toronto.

Such information not only provides new possibilities about the design of painkillers, but also helps people understand why many drugs fail to control chronic pain.

Painkillers is already there in the long term. However, chronic pain management in hospital and the treatment of cancer and other diseases is still far enough in many places.

Zhuo and his colleagues found elevated levels of protein kinase M zeta emzim in the area of the brain called the anterior cingulate cortex in injured rats.

To confirm the function of this enzyme, they get rid of the rat gene in the group that is believed responsible for the increased production of the enzyme. Scientists later found that the mice had felt little or no pain after being given drugs that block these enzymes.

"A lot of painkillers that do not work for chronic pain, particularly neuropathic pain. There is great need for effective new drugs to control chronic pain," wrote Zhuo.



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